SuppRankedTop 10 enzymes brands on Amazon (estimated revenue)
Ranked by estimated monthly revenue from Amazon's Enzymes Best Sellers top 100. Updated October 15, 2026.
Physician's CHOICE is the top-selling enzymes brand on Amazon by estimated revenue, at about $4.5M/mo from 3 products in the Enzymes Best Sellers top 100. That is about 38% more than #2 Enzymedica (~$3.3M/mo). The list is fairly concentrated: the top 3 brands take about 36% of its estimated sales and the top 10 about 67%, spread across 52 brands in total. All figures are modeled estimates, not Amazon data.
| # | Brand | Est. revenue/mo |
|---|---|---|
| 1 | Physician's CHOICE16% share · best #1 | $4.5M |
| 2 | Enzymedica12% share · best #4 | $3.3M |
| 3 | NOW Foods8% share · best #5 | $2.2M |
| 4 | Pure Encapsulations6% share · best #8 | $1.6M |
| 5 | Zenwise6% share · best #2 | $1.6M |
| 6 | LactoJoy4% share · best #30 | $1.2M |
| 7 | Snap Supplements4% share · best #74 | $1.2M |
| 8 | Bloom Nutrition4% share · best #12 | $1M |
| 9 | Nutricost4% share · best #23 | $1M |
| 10 | Doctor's Best3% share · best #10 | $878K |
The top 10, brand by brand
1. Physician's CHOICE
~$4.5M/mo est. revenue (16% of this list) and ~147K units/mo from 3 products; best position #1. Its highest-ranked product here is Physician's CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16… at #1. Overall it ranks #37 of 3,479 brands.
2. Enzymedica
~$3.3M/mo est. revenue (12% of this list) and ~113K units/mo from 9 products; best position #4. Its highest-ranked product here is Enzymedica Digest Gold, Maximum Strength, ATPro Energy Support - 90 Caps… at #4. Overall it ranks #78 of 3,479 brands.
3. NOW Foods
~$2.2M/mo est. revenue (8% of this list) and ~95.8K units/mo from 8 products; best position #5. Its highest-ranked product here is Now Foods Super Enzymes, 180 Capsules at #5. Overall it ranks #1 of 3,479 brands.
4. Pure Encapsulations
~$1.6M/mo est. revenue (6% of this list) and ~39.3K units/mo from 5 products; best position #8. Its highest-ranked product here is Pure Encapsulations Digestive Enzymes Ultra, 90 Capsules | Vegetarian Digestive… at #8. Overall it ranks #3 of 3,479 brands.
5. Zenwise
~$1.6M/mo est. revenue (6% of this list) and ~58.4K units/mo from 2 products; best position #2. Its highest-ranked product here is Zenwise Health Digestive Enzymes, Probiotics, for Gut Health Bloat - 180 CT… at #2. Overall it ranks #191 of 3,479 brands.
6. LactoJoy
~$1.2M/mo est. revenue (4% of this list) and ~28.9K units/mo from 2 products; best position #30. Its highest-ranked product here is LactoJoy Lactase Pills 14,500 I 45 Pieces I Powerful Lactase Enzymes for… at #30. Overall it ranks #391 of 3,479 brands.
7. Snap Supplements
~$1.2M/mo est. revenue (4% of this list) and ~30K units/mo from 1 product; best position #74. Its highest-ranked product here is Snap Supplements Gut Health Supplement & Organic Spirulina Chlorella Bundle… at #74. Overall it ranks #62 of 3,479 brands.
8. Bloom Nutrition
~$1M/mo est. revenue (4% of this list) and ~30K units/mo from 1 product; best position #12. Its highest-ranked product here is Bloom Nutrition Superfood Greens Powder, Orange Passionfruit, 30 Servings… at #12. Overall it ranks #145 of 3,479 brands.
9. Nutricost
~$1M/mo est. revenue (4% of this list) and ~46.2K units/mo from 4 products; best position #23. Its highest-ranked product here is Nutricost Bromelain (500mg) 120 Vegetarian Capsules, Gluten Free | Bromelain… at #23. Overall it ranks #2 of 3,479 brands.
10. Doctor's Best
~$878K/mo est. revenue (3% of this list) and ~28.3K units/mo from 4 products; best position #10. Its highest-ranked product here is Doctor's Best Nattokinase 2000 FU Supplement, for Men & Women, 270 Veg Caps… at #10. Overall it ranks #24 of 3,479 brands.
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Full Enzymes ranking
All 52 brands in the list, ordered by rank strength, plus the top 10 products.
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