SuppRankedBest-selling enzymes brands on Amazon
52 brands have products in the Amazon Best Sellers top 100 for Enzymes. Ordered by how strongly each brand ranks in this list (higher positions and more products count more). List as of October 15, 2026.
Top 10 Enzymes products
| # | Product | Est. revenue/mo |
|---|---|---|
| 1 | Physician's CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16 Enzyme… Physician's CHOICE | $1.3M |
| 2 | Zenwise Health Digestive Enzymes, Probiotics, for Gut Health Bloat - 180 CT | Multi… Zenwise | $1.4M |
| 3 | Physician's CHOICE Advanced Gut Health Bundle: 60 Billion Probiotics 30ct + Digestive… Physician's CHOICE | $1.2M |
| 4 | Enzymedica Digest Gold, Maximum Strength, ATPro Energy Support - 90 Caps | Digestive… Enzymedica | $1M |
| 5 | Now Foods Super Enzymes, 180 Capsules NOW Foods | $489K |
| 6 | NOW Supplements, Quercetin with Bromelain, 240 Veg Caps NOW Foods | $895K |
| 7 | Micro Ingredients Nattokinase 10,000 FU Per Serving, 240 Veggie Capsules | Natural Natto… Micro Ingredients | $515K |
| 8 | Pure Encapsulations Digestive Enzymes Ultra, 90 Capsules | Vegetarian Digestive Enzyme… Pure Encapsulations | $594K |
| 9 | Nattokinase Supplement, 4,000 FU per Serving, 120 Capsules | Fibrinolytic Enzyme… Brand unconfirmed | $287K |
| 10 | Doctor's Best Nattokinase 2000 FU Supplement, for Men & Women, 270 Veg Caps | Supports… Doctor's Best | $495K |
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Top 10 Enzymes brands by revenue
Physician's CHOICE, Enzymedica, NOW Foods and seven more, with each brand's estimated revenue share.
See the top 10 →Head-to-head comparisons
Enzymes brands on Amazon: FAQ
What is the best-selling enzymes brand on Amazon?
By estimated revenue, Physician's CHOICE is the best-selling enzymes brand on Amazon right now, at roughly $4.5M/mo from 3 products in the Enzymes Best Sellers top 100 (best position #1). These are SuppRanked's modeled estimates from public Amazon Best Sellers ranks and list prices (October 15, 2026), not official Amazon sales data.
What is the #1 best-selling enzymes product on Amazon?
On October 15, 2026 the #1 product in Amazon's Enzymes Best Sellers list was Physician's CHOICE Digestive Enzymes for Bloating & Digestion - Fast-Acting 16 Enzyme Formula with… from Physician's CHOICE, with an estimated 67K units and ~$1.3M in revenue per month. Ranks change hourly, so check Amazon for the live list.
How many enzymes brands are in Amazon's top 100?
52 distinct brands have at least one product in the Enzymes top 100. The 10 biggest by estimated revenue account for about 67% of the list's estimated sales, and the top 3 for about 36%.
How much do the top enzymes products sell on Amazon?
We estimate the top 100 enzymes products together bring in about $29.9M a month at list price, before returns, discounts and fees. Treat it as an order-of-magnitude figure. These are SuppRanked's modeled estimates from public Amazon Best Sellers ranks and list prices (October 15, 2026), not official Amazon sales data.
How are these rankings calculated?
We read the public Amazon Best Sellers list daily, match each product to its brand, estimate monthly units from Amazon's “bought in past month” badges and sales-rank curves, and multiply by list price. Full details are on the methodology page.